My wifes iphone battery died and won't come on?

My wife just called from work to say that her phone died and when she plugged it back in it tells her to connect to itunes and shows the USB symbol, like the way it come from the factory. Does anybody know why and what she has done or what to do? Thanks

Added (1). Is there any danger of a real answer of meaning. The phone is with her at work and simply ran out of battery. She says she turned it back on and that is what the phone says. Is this possible or has she formatted it or messed with it?

YOU NEED TO TAKE IT OUT OF THE COMPUTER AFTER ITS CHARGERED OHH WOW!

Because she's a woman

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