Do you have to re-calibrate an iphone screen if you replace it?

My new screen comes in today and I need to knowonce I replace it if I have to calibrate the new screen.

Apple's iPhones, like most other modern touchscreen phones, use capacitive screens. So there's no calibration required or possible.

If you stick to using a genuine Apple screen, or an OEM version (exactly the same part from the same supplier Apple uses, but without Apple branding on the packaging) then there's rarely any problem.

Non-Apple/non-OEM screens can break and scratch more easily, may have duller colours, uneven backlighting, and less touch sensitivity. If the options in the Accesibility menu (Settings>General>Accessibility) don't make any difference to those then there's nothing you can do except to adapt yourself to accept them.