Can I escape from being loner and loser type kid?

I'm 22 years old guy.
I have no friends at all, never even had any dates or relationship with any girls.
I was loner for pretty much for my entire life, no one really knew me that well.
I was type of guy who was always taken advantage of, ripped off by someone, and everyone around me pretty much just used me for their own goods. Nobody really cared about me or even like me.
When I say hi to people, they ignore, when I see people from high school, they all ignore me.
I had people who I used to hang out with, but I stopped contacting them and I just ignored them cause I just did not want to be around them.
I have zero contacts on my Iphone now.
Am I considered as a loser?
I want to change myself, and want to have relationship with girls and have life, but it is really hard for me to even make a friend.
I have limited social skill, I'm horrible at talking, I just can't keep up with conversation with people.
Whenever I try to make friends, they always just use me and take advantage of me for their own goods, they do not care about me.
I'm just tired of being taken advantage of and used by people ya know?
What should I do, any Advice?

Added (1). @Warren, should I give up?

I doubt you'll make you're too into yourself… Smiling might help