If i update my jailbroken iphone to the ios 6, will i lose my data?

Okay, i have ios 4.2.6 on my jailbroken iphone and want to update to the ios 6. If i do so, will i lose all my data, or just what i have from cydia, installous, mewseek, mxtube, etc? Also, if i were to delete all my jailbroken apps before updating, would it still delete all data? And, if you are going to say to back up my phone before doing so, can you help with that as well, i'm running off of a macbook pro and i'm not sure exactly what to do. Any help?

You will lose all jailbreak data no real bought data such as apps or videos
to back up just go to itunes right click on the idevice and click backup

Yes, you will.

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